Thursday, 24 May, 2018

Researchers discover cure for common cold with a drug molecule

Common cold cure on horizon after new drug successfully kills multiple strains of the virus Why scientists are close to finding a cure for the common cold
Marlene Weaver | 15 May, 2018, 21:25

The problem with the common cold is that it isn't just one virus. To top it all, the viruses develop quickly which is why they tend to gain resistance to any drugs rapidly. The viruses also evolve quickly to become resistant to anti-viral drugs.

But researchers at Imperial College London have focused on a protein inside human cells called N-myristoyltransferase (NMT).

It is due to these reasons that the best way to treat the common cold is by maintaining a good hygiene practice to avoid spreading of the virus and to manage the runny nose and scratchy or sore throat for the next 10 days that it may take to recover fully.

Scientists in the United Kingdom have developed a new molecule that prevents viruses responsible for the sickness from replicating inside human cells - and if further testing confirms the compound is safe, we could be looking at the unthinkable: a cure.

Previous attempts to create such a drug were limited in capability as they often caused unsafe side effects.

See The Official Teaser & Poster For "Bohemian Rhapsody" Biopic
Check out the tiny teaser below and prep yourself for the full trailer tomorrow. We're delighted to see that Bohemian Rhapsody kicks off with that moment.

A 1913 poster about the common cold.

Lead researcher Professor Ed Tate, from the Department of Chemistry at Imperial, said: "The common cold is an inconvenience for most of us, but can cause serious complications in people with conditions like asthma and COPD".

Laboratory tests showed how an experimental drug stopped the rhinovirus - the predominant cause of the common cold - hijacking a human protein to build the protective shell, or "capsid". The molecule could also work against the poliovirus and the virus that causes foot and mouth disease. Without the protein shield, the virus's genetic heart of RNA is exposed and vulnerable - and the virus can not replicate.

The medicinal chemistry team in the Tate group at Imperial, led by Dr Andy Bell (who previously invented Viagra as a researcher at Pfizer), were originally looking for compounds that targeted the protein in malaria parasites.

By inventing a novel way to combine the two, they created a molecule, codenamed IMP-1088, which is more than a hundred times more potent than previous molecules targeting the protein in humans. In this study, the researchers found no side effect to human cells. But some of the side effects were toxic.

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