Saturday, 20 January, 2018

Painless Flu Vaccine Patch?

Microneedle patches for flu vaccination prove successful in first human clinical trial Finally, a needle-free way to get a flu vaccine
Marlene Weaver | 29 June, 2017, 08:54

The researchers also are working to develop microneedle patches for use with other vaccines, including measles, rubella and polio.

Researchers said the patch was "just as effective in generating immunity against influenza". All you have to do is press the patch to your skin. Seroconversion percentages from the patches were significantly higher than those in participants who received placebos (P .0001) and similar to those for intramuscular injections (P .01). That way, there are no sharp objects to dispose of like there might be with a flu shot, making it easier for people to put the patch on themselves. Only difference between these systems is that regular flu injections go all the way through and into muscle whereas the patch punctures the most upper layers of the skin, overall the medicine penetrates in the body. None of the participants had received a flu vaccine during the previous influenza season.

Only about 40 percent of adults in the United States get a flu shot every year, despite the potentially severe consequences for their health.

Mice given a single H1N1 vaccine through the skin using a coated metal micro needle patch as well as mice vaccinated through subcutaneous injection were 100 percent protected against a lethal flu virus challenge six weeks after vaccination.

Instead, flu vaccinations might look something like a Band-Aid.

People may soon be able to get a flu vaccine without the needle.

"Having the option of a flu vaccine that can be easily and painlessly self-administered could increase coverage and protection by this important vaccine", Dr. Nadine Rouphael, first author of the study and professor at the Emory University School of Medicine said in a news release.

Cris "Cyborg" Gets New Opponent For UFC 214
Her most recent victory earned her the interim Invicta FC featherweight title, which was later installed to full time champion. Both bouts took place at a catchweight of 140 pounds, with UFC 214 set to be her first trip to the Octagon as a featherweight.

This microneedle patch was created by researchers at the Georgia Institute of Technology and the Centers for Disease Control and Prevention.

Most new yoga pain occurs in the shoulders, elbows, wrists, and hands, and lasts longer than three months on average, but is usually not severe enough to prevent participation.

The overall number of adverse events was similar between the injection and patch groups, and between the group given the patch by a healthcare-professional and the group who applied the patch themselves. Participants were divided into four groups, one of which received an injection whilst the others wore the microneedle patch for twenty minutes.

Prof Mary Horgan, a consultant in infectious diseases at Cork University Hospital, said that while the patch was at very early clinical trial stage, the big benefit would be that it is self-applied, and eliminates "needle phobia". The team also found that the drugs in the patch could stay viable for over a year, without the need for refrigeration.

While the idea of a "no injection" vaccine sounds great if you don't like injections, they may have a much bigger impact in parts of the world where it's hard to reach and administer vaccines with a continuous cold chain, and where health care staff are in short supply.

Both approaches were found to cause tenderness in some patients, but 96% of those vaccinated with the patch said they found the technique pain-free.

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